ABSTRACT
OBJECTIVE:To investigate the therapeutic efficacy and safety of mycophenolate mofetil combined with glucocorti-coid in the treatment of refractory idiopathic thrombocytopenic purpura (ITP). METHODS:134 cases of refractory ITP were ran-domly divided into observation group and control group,with 67 cases in each group. Control group was given Prednison acetate tablet orally,0.5 mg/kg each day,morning and evening. Observation group was additionally given Mycophenolate mofetil dispers-ible tablet,1 g/time,bid. A treatment course lasted for 3 weeks,and both groups received 3-5 courses of treatment. Clinical effica-cy of 2 groups were compared as well as the change of PLT before and after treatment,satisfaction degree of treatment and adverse event. RESULTS:The total effective rate of observation group (91.04%) was significantly higher than that of control group (74.63%),with statistical significance(P<0.05);PLT of observation group was significantly greater than that of control group 7, 14 and 21 d after treatment,with statistical significance(P<0.05);total satisfactory degree of observation group was significantly higher than that of control group (89.55% vs. 80.60%),and the incidence of adverse event was significantly lower than control group(2.99% vs. 10.44%),with statistical significance(P<0.05). CONCLUSIONS:Mycophenolate mofetil combined with glu-cocorticoid can improve clinical efficacy,PLT and satisfactory degree significantly in the treatment of refractory ITP with good safety.
ABSTRACT
Idiopathic thrombocytopenic purpura (ITP),also called immune thrombocytopenia more frequently by the international,is the most common acquired hemorrhagic disease characterized by thrombocytopenia,presence of anti-platelet antibody in the plasma,with increased or normal megakaryocytes with abnormal maturation.About 70％ of 1TP patients recover spontaneously within 6 months,while a small proportion of patients will transform to persistent,chronic or refractory idiopathic thrombocytopenic purpura.New immunosuppressive agents and thrombopoietin for the treatment of children with refractory ITP have been developed.Dramaric progresses in the diagnostis,severity assessment and treatment of refractory ITP have been made recently,which is comprehensively illustrated in this review.
ABSTRACT
Objective To explore the syndrome distribution laws of refractory idiopathic thrombocytopenic purpura (RITP), and the relevance between various syndromes and gender, age, laboratory indicators, to reveal the essence of TCM syndrome and provide a reasonable and standard TCM treatment principle. Methods TCM syndrome, gender, age and laboratory indicators of 75 cases of RITP were studied retrospectively and analized statistically. Results Qi deficiency and blood stasis is the major syndrome, and Yin deficiency is the secondary syndrome. Compare with others, the patients with qi deficiency and blood stasis syndrome were older, and had longer disease courses and more severe conditions. Conclusion One of TCM intervention treatment principles for RITP is invigorating qi and yin, promoting blood circulation and removing blood stasis.